Regulating basal body replication
نویسندگان
چکیده
منابع مشابه
Regulating the transition from centriole to basal body
The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase. Stringent regulations govern conversion between these two states. Although the molecular mechanisms have not been fully elucidated, recent findings have begun to shed light on pathways that regulate the conversi...
متن کاملBasal Body Replication and Ciliogenesis in a Suctorian, Tokophrya Infusionum
Basal body replication and ciliogenesis in Tokophrya infusionum were studied in synchronized cultures. Basal body replication occurs during the 1st hr of reproduction, which in Tokophrya is by internal budding. The number of basal bodies increases from about 20 to over 300 within this period. New basal bodies develop in association with mature basal bodies; they are formed at right angles to th...
متن کاملBasal body timing
ggregation of ␥-tubulin, pericentrin, and myosin II (GPM) precedes de novo basal body assembly, according to a report from Kim et al. on page 719. The number of basal bodies formed is controlled by the duration of ␥-tubulin phosphorylation. Until now, it has not been clear whether basal body and centriole formation occurred before or after clouds of pericentriolar material take shape. To answer...
متن کاملCentrin deficiency in Chlamydomonas causes defects in basal body replication, segregation and maturation.
Centrin, a 20 kDa calcium-binding protein, is a constituent of contractile basal body-associated fibers in protists and of various centrosomal structures. A construct inducing centrin RNAi was used to study the effect of centrin deficiency in Chlamydomonas. Transformants contained variable amounts of residual centrin (down to 5% of wild-type) and lacked centrin fibers. They displayed a variable...
متن کاملAEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome.
Trypanosoma brucei causes human African trypanosomiasis (HAT). The pyrrolopyrimidine AEE788 (a hit for anti-HAT drug discovery) associates with three trypanosome protein kinases. Herein we delineate the effects of AEE788 on T. brucei using chemical biology strategies. AEE788 treatment inhibits DNA replication in the kinetoplast (mitochondrial nucleoid) and nucleus. In addition, AEE788 blocks du...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1716iti4